Science behind T.O.M.

A drink mix that can help replenish the loss of those essential elements of the body
during Time Of Month

T.O.M. is a supplement infused with nutritionals, minerals, micro & macronutrients, flavonoids and anti-oxidants. It is a drink mix that can help replenish the loss of those essential elements of the body during Time Of Month. After a few years of research and evaluating a lots or research journals and findings, we created this very balanced formula that a woman need during her time Of Month that will support to bring a normal, healthy attitude during PMS.

Women with PMS reported reduced work productivity, interference with hobbies and greater number of work-days missed for health reasons. In addition, women with PMS experience an increased frequency of ambulatory health care provider visits and were more likely to accrue more than $500 in PCP visit costs over 2 years.1 ,2

The uterus during period? What happens to

It has been established that the size of the uterus grows significantly towards the end of the menstrual cycle. In a study, changes in the size of non-pregnant uterus were measured by B-scan ultrasonography. Uterine size in different stages of the menstrual cycle was measured ultrasonically in 16 women, whose periods were confirmed to be ovulatory, both by basal body temperature (BBT) and by the radioimmunological measurement of plasma estradiol and progesterone. In addition to the above mentioned, the examination was performed on a woman of child-bearing age with disturbances in her menstrual cycle. Hormone measurements indicated that her period was anovulatory. In all cases the size of the uterus grew significantly

Most people especially know about how a uterus looks like. However, here is a clear picture of human uterus:

Screen Shot 2017-04-10 at 9.11.35 PM

Photo: Human uterus

Blood is amazing. All the energy-giving substances coming from food are carried along by the blood where they are needed.  It is very important to help your blood by eating healthy so that you get all the vitamins and minerals your body needs. Some girls have very heavy periods when they start having periods, and if they do not get enough iron, essential elements and other nutrients in their diet they can become anemic and feel tired much of the time. This is more common to women who are vegetarian, don’t eat red meat or have a very busy lifestyle and cannot eat balanced, healthy diet.  Bottom-line is, just before and during period uterus draws essential fluids, nutrients and elemental matters from diet with higher blood-flow. If those items are not available in daily diet, it draws from other parts of the body cells. This process can lead to malnutrition as-a- whole or malnutrition on a specific essential element.
There are hundreds of researches have been done for individual items that has been helpful for reliving the different symptomatology of Time Of Month. Thousands of pages can be written on beneficial effects of each item in T.O.M. Here is some brief description in very simple language in a question and answer format:

To visualize the difference between non-menstruating and menstruating uterus can be shown by the following picture:

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Photo: Visualization and comparison between non-menstruating and menstruating uterus

Why Women have different nutritional needs?

Caloric Need

  • Men generally have an overall larger body (both height and weight) and greater muscle mass than women, they also have increased caloric needs compared to women.
  • The average-sized, moderately physically active 30-year-old female needs about 2000 calories per day while her male counterpart needs about 2800 calories per day. Even if they were the same height and weight, the
    Dietary Reference Intakes (DRIs) approximate that the man burns about 400 calories more per day than the woman.

Although the recommended breakdown of carbohydrate, protein, and fat are the same for both genders, because men generally need more calories, they also require higher total intake of each of the macronutrients. All protein and other nutritional products in the market are made as “One-Size-Fits-All” style. Besides the caloric intake, women need different elemental, macro and micronutrients than men’s need on those items. The most important thing is, men do not loose blood every month like women do. That  is why specially formulated mixture of nutritional is recommended for women of menstruating ages.

woman needs to maintain a healthy lifestyle? What are the most important elemental minerals a menstruating age

The following some elemental minerals women need just before and during menstruation:


For women of childbearing age, blood loss through menstruation can lead to iron deficiency. Red blood cells have the important job of carrying oxygen around the body. They also contain a protein called Hemoglobin. Hemoglobin contains Iron which combines with oxygen to give Hemoglobin a red color and that is why our blood is red. There are millions of red blood cells in one small drop of blood. Thus replenishing Iron is very important to support the body to produce new blood cells that were lost during menstruation. The Institute for Medicine of the National Academies recommends a daily allowance of 18 milligrams of iron for women aged 18 to 50. During pregnancy a woman’s requirements are even greater. Men in that same age range need just 8 milligrams daily.There are few other complications can happen during the Time Of Month because of iron deficiency that most people do not know.

Iron deficiency is also associated with abnormalities of the soft mucosa of the mouth and gastrointestinal tract leading to angular stomatitis (cracking and roughness on one or both sides of lips), glossitis, esophageal webs, and chronic gastritis. Spoon-shaped fingernails (koilonychia) may be present. The eating of nonfood material (pica) or a craving for ice (pagophagia) is also associated with iron deficiency. 4 ,5


Another very important area to watch is calcium.

Results from multiple studies suggest that calcium deficiency, dysregulation of calcium metabolism and functions of calcium-related hormones may contribute to premenstrual syndrome (PMS).Many types of dietary supplements have been advocated for the reduction of certain symptoms of premenstrual syndrome (PMS). However, one supplement-calcium has been demonstrated to be of significant benefit in a large, rigorous, double-blind, placebo-controlled trial. 6

“Women build bone into their mid-20s, and they need to eat calcium-rich foods to promote bone density,” says the research.

In another randomized double-blind placebo controlled trial study showed that,  increasing calcium intake reduced mood, concentration, and behavior symptoms generally, reduced pain during the menstrual phase of the cycle, and reduced water retention during the premenstrual phase


Manganese is a trace mineral that is present in tiny amounts in the body. It is found mostly in bones, the liver, kidneys, and pancreas. Manganese helps the body form connective tissue, bones, blood clotting factors, and sex hormones. It also plays a role in fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese is also necessary for normal brain and nerve function.Manganese is a component of the antioxidant enzyme superoxide dismutase (SOD), which helps fight free radicals. Free radicals occur naturally in the body but can damage cell membranes and DNA. They may play a role in aging, as well as the development of a number of health conditions, including heart disease and cancer. Antioxidants, such as SOD, can help neutralize free radicals and reduce or even help prevent some of the damage they cause.

In one well-designed clinical study, women who ate 5.6 mg of manganese in their diets each day had fewer mood swings and cramps compared to those who ate only 1 mg of manganese. These results suggest that a manganese-rich diet may help reduce symptoms of PMS. Another clinical study found that patients with PMS had significantly lower amounts of calcium, chromium, copper, and manganese in their blood than those without PMS.8

In another study, ten women with normal menstrual cycles completed the Menstrual Distress Questionnaire each cycle during a 169-day, live-in metabolic study of calcium and manganese nutrition. Women were assigned in a double-blind, Latin-square manner to each of four 39-day dietary periods. The result showed lower dietary manganese increased mood and pain symptoms during the premenstrual phase.9

Besides these, low levels of manganese in the body can contribute to infertility, bone malformation, weakness, and seizures. It is fairly easy to get enough manganese in your diet — this nutrient is found in whole grains, nuts, and seeds — but some experts estimate that as many as 37% of Americans do not get the recommended dietary intake (RDI) of manganese in their diet. The American diet tends to contain more refined grains than whole grains, and refined grains only provide half the amount of manganese as whole grains.


Magnesium is one of the most essential mineral in the human body, connected with brain biochemistry and the fluidity of neuronal membrane. A variety of neuromuscular and psychiatric symptoms, including different types of depression, was observed in magnesium deficiency.10 Magnesium is important in more than 300 chemical reactions that keep the body working properly. Dietary intake of magnesium may be low, particularly among women. Magnesium is also used for treating anxiety, chronic fatigue syndrome (CFS), fibromyalgia, leg cramps during pregnancy, migraine headaches, weak bones (osteoporosis) and premenstrual syndrome (PMS).11

Most of the early signs of magnesium deficiency are neurological or neuromuscular defects that may develop with time into anorexia, nausea, muscular weakness, lethargy, weight loss, hyper-irritability, hyper-excitability, muscular spasms, tetany and convulsions. The recommended daily intake of magnesium is 320mg for females and 420mg for males which can be achieved through the diet, however sometimes this is not possible. So a moderate amount of magnesium should be supplemented in order to maintain a healthy lifestyle.12

woman needs other than caloric requirements? What are most important vitamins a menstruating age

Vitamin B6 (Pyridoxine)

Vitamin B6 regulates hormone levels and of course the symptoms of PMS are mostly caused by the hormone imbalance that occurs during menstruation. Vitamin B6 also reduces the fluid retention that causes bloating and cramps.
A randomized double-blind crossover trial was conducted to study the effects of pyridoxine (vitamin B6). Sixty three women aged 18-49 years, identified by means of a general practice based survey of menstrual patterns in the community, entered the trial. All of the women had noticed moderate to severe premenstrual symptoms during the previous year. Thirty seven women completed 6 months and 32 completed the full 7 months. The results of the study show Vitamin B6 (Pyridoxine) to significantly affect emotional type symptoms (depression, irritability, and tiredness) symptoms of premenstrual syndrome.13
Bertone-Johnson and colleagues recently found that women with high dietary intake of the B vitamins thiamine and riboflavin had 25 to 35 percent lower risks of developing PMS. Results from the present study are “consistent with these findings, and suggest that improving B vitamin status in women with PMS may both reduce menstrual symptom severity and lower hypertension risk,” they write.14

Folic Acid

Folic acid (folate) is a vitamin and is needed to make new cells in your body, including red blood cells. Human body does not store very much folic acid. The body needs a regular fresh supply to keep healthy. Red blood cells are made in our bone marrow and millions are released into our bloodstream each day. When a good amount of red blood cells are lost during period, a constant new supply of red blood cells is needed to help the body to make new batch of red blood cells.
As you read in our previous sections red blood cells contain chemical called hemoglobin. Hemoglobin binds to oxygen and takes oxygen from your lungs to all parts of your body. To make red blood cells and hemoglobin constantly you need a healthy bone marrow and nutrients such as iron and certain vitamins, including folic acid (folate).
Low level of folic acid in body, as well as its complications, causes folate deficiency leading to “Tired Blood” (anemia) and the inability of the bowel to absorb nutrients properly.

Vitamin A

Both retinol and ethanol are alcohols. Thus there is a potential for overlap in the metabolic pathways of these two compounds. Competition with each other for similar enzymatic pathways has been reported, while other retinol and alcohol dehydrogenases show greater substrate specificity. Ethanol consumption results in a depletion of hepatic vitamin A concentrations in animals and in humans. 15,16
Bottom-line is, drinking alcohol can reduce body vitamin-A level that may lead to Vitamin-A deficiency.
Symptoms are often present with a vitamin A deficiency. People who exhibit signs of a vitamin A deficiency will have problems in their eyes like night blindness, swelling in the eyes (conjunctivitis), dry eye syndrome (xerophthalmia), color-blindness, dry corneas (keratomalacia), abnormal tolerance of light (photophobia), and complete blindness.
Symptoms associated with the hair and nails would be present like dry hair, peeling nails, and ridges in the nails. Skin problems would present themselves as acne, skin infections, scleroderma, dry skin, and skin cancers. Other symptoms include reproductive problems, bad teeth, slow bone development, cardiovascular problems, weakened immune systems, weight loss and loss of smell, taste or appetite.
Hormones can cause minor deficiencies in women during menstruation that can be adjusted by adding vitamin A to the diet regularly. When hormones fluctuate around the time of a period, estrogen and progesterone levels start to adjust at rapid rates.
When this happens, vitamin levels in the body fall and the onset of PMS symptoms occurs. Vitamin A is directly linked to skin problems, fatigue, and heavy bleeding. When the hormones fluctuate, vitamin A falls, women experience outbreaks of acne, exhaustion and heavy bleeding during their periods – many of the symptoms of PMS.

Vitamin B12

Vitamin B12 or Cyanocobalamins is the known stress vitamin for the human body. B12 is one of the most important vitamins and minerals in the body. It is used by every system in the body which is why it is given to elderly people with fatigue and low energy. It can produce an almost immediate energy boost in both the elderly and in the woman suffering from PMS. Unlike most B vitamins, B12 does not pass through waste and can be held by the body for a number of years. It promotes energy and less fatigue along with a better balance of all body functions. It also improves the cognitive functions.
Vitamin B12 is effective in treating mood swings, anxiety and depression during your period. Without B12 you will experience a lot more of this. There is a study that validates the experience of millions of women.
The Department of Public Health published a double-blind study in the journal for Clinical and Human Nutrition that showed an intake of 5 milligrams of vitamin B12 twice per week drastically reduced the effects of depression, tiredness, and irritability in twenty eight patients of the study. These are symptoms many women face during PMS and getting a dosage of 10 milligrams per week will help to reduce the PMS symptoms.

Vitamin D3

Moderate to severe premenstrual syndrome (PMS) affects 8-20 percent of premenopausal women. Previous studies suggest that high dietary vitamin D intake may reduce risk.17
Researchers queried about 3,000 women from 1991 to 1999 as part of the Harvard Nurses’ Health Study to determine how much calcium and vitamin D women ingested through their diet and supplements. Researchers did not measure how much vitamin D participants got from sunlight.
None of the women in the study had experienced PMS when the study began. The authors tracked how many of the women developed PMS, and found that women who consumed high amounts of vitamin D through food or supplements had a 40 percent lower chance of developing PMS than those with lower vitamin D intake.
PMS affects women before their menstrual period begins with several symptoms, including depression, irritability, abdominal cramping and headaches. Dr. Chandra Graham, an assistant professor of obstetrics at the University Of Maryland School Of Medicine, said 40 to 50 percent of women experience symptoms, but only 10 to 15 percent have severe PMS.

Vitamin E

Menstrual migraine, on the other hand, is associated with increased prostaglandin (PG) levels in the endometrium, indicating a role for vitamin E, which is an anti-PG.18

a woman especially during the Time Of Month? What are the common micronutrients needed for

Micronutrients are nutrients required by organisms throughout life in small quantities to orchestrate a range of physiological functions. For people, they include dietary trace minerals in amounts generally less than 100 milligrams per day, as opposed to macro-minerals, which are required in larger quantities.

There are few other micronutrients that are helpful in general female health and during time of month include Zinc, Phosphorus and Copper.

Mother Nature can provide us to help relief PMS and how? What plants and herbs

Mother Nature has so much resources for different ailment that humans yet to discover very little of it. Considering these aspects TOM is created with a balanced formula that should help replenish those lost nutrients in the body along with that this product is infused with other very essential ingredients that are naturally derived. These ingredients have been used for the Time of Month in different parts of the world since long before the modern synthetic medicines arrived.
There have been lots of reports on different naturally occurring ingredients have been reported that relieves menstruation related problems.
Some are from American herbalists, ancient natural Ayurvedic, homeopathic and Unan traditional medicine.
For example, in the 18th and 19th centuries herbalists used wild yam root, a naturally grown plant in North America used by Native American Indians for balancing the hormonal ups and downs during time of month and to relieve menstrual cramps. In the 1950s scientists discovered that the roots of wild yam contain Diosgenin. Diosgenin is a phytoestrogen or plant based estrogen that can be chemically converted into a hormone called progesterone.19 ,20 ,21
There are few natural proprietary blend contained in the formulation of TOM. For example, Black Cohosh, Red Raspberry Extract and Evening Primrose Oil. There are huge amount of research have been done on these natural ingredients for relieving PMS.
TOM is natural and not a drug or synthetic hormone. It does not have any habit forming properties.

Chocolate on the Brain? What is the mechanism of action of

Another ingredient, REAL Dutch chocolate is used in TOM formulation.
There a huge numbers of research articles published in medical and pharmaceuticals journals about Chocolate’s positive effects on the brain.
Chocolate can affect the brain by causing the release of certain neurotransmitters.
Chocolate of TOM can boost Neurotransmitters like phenylethylamine. As a result it will help leading to feelings of excitement and alertness.
Neurotransmitters are the molecules that transmit signals between neurons. The amounts of particular neurotransmitters we have at any given time can have a great impact on our mood.
One of the more unique neurotransmitters released by chocolate is phenylethylamine. This so called “chocolate amphetamine” causes changes in blood pressure and blood-sugar levels leading to feelings of excitement and alertness. It is also to remember that not all chocolate is created equal. The strength of chocolate greatly depends on how it is manufactured. I have used a specific kind of natural Dutch chocolate that is very high on few neurotransmitters, flavonoids and caffeine free.

difference between T.O.M. and a regular multivitamin formula? What is the

Nutrients are used by female body at an accelerated rate during hormonal changes in PMS. If you don’t have enough of these nutrients, or perhaps their food habits gives low amount of some nutrients that cause them to need higher potencies of these nutrients. Thus these deficiency symptoms can manifest as PMS discomfort. Taking these nutrients in high enough potencies helps reduce the problems. Additionally, the herb used in TOM help improve the hormonal balance, along with other matters like water retention, mood/emotional changes and breast tenderness.
A regular multi-vitamin is formulated to give a One-Size-Fits-All concept. During Time Of Month women need specific micro and macronutrients in a higher rate. To provide that T.O.M. is a perfect concoction specific for supplementing during that unpleasant days that women go thru.
Our goal is to:

  • Individualized nutritional care for the Time of Month
  • Targeted care and
  • Care with precision

What should you do to avoid extensive PMS?


A research showed among a group of college students in the United States, consumption of caffeine-containing beverages was associated with increases in both the prevalence and severity of PMS. Moreover, the more caffeine women consumed, the more likely they were to suffer from PMS. Therefore, many nutritionally oriented doctors recommend that women with PMS should avoid sources of caffeine. The reason behind that is, caffeine increases urinary loss of calcium.

Avoid or limit Alcohol

Despite any evidence of wine’s effectiveness as a muscle relaxant—which could arguably make it useful in calming cramps—the fact is the overall impact of alcohol on a system going through PMS is negative. Booze can actually increase physical symptoms like breast tenderness and headaches and exacerbate mood fluctuations (which alcohol already does when we’re not dealing with PMS). Even the promise of reduced cramping is likely less than guaranteed. According to The New York Times, alcohol consumption “may increase the risk for prolonged cramping (dysmenorrhea) during menstruation.” Alcohol can also contribute to magnesium deficiencies, and magnesium may actually help with bloating.

Do not overload on sugar

If you’re craving sugar, you’re craving it for a reason. That reason is shifting levels of the hormones estrogen and progesterone, which can also decrease levels of the chemical serotonin in the brain. These changes may affect a woman’s mood and trigger PMS symptoms.

Bring some healthy calories

In fact, studies have shown that some women with PMS may take in 200 to 500 more calories a day. Those additional calories typically come from fats, carbohydrates, or sweet foods. So the best option to add some protein in your daily diet during Time Of Month.


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2. Hammond G, Yarlas A, Yang M, Gricar J., Assessing Productivity Impairment in Premenstrual Symptom (PMS) and Premenstrual Dysphoric Disorder (PMDD),14th ISPOR Presentation, May 16-20, 2009.

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6. Bendich A,. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. J Am Coll Nutr. 2000; Feb;19(1):3-12.

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12. Heaton S, MAGNESIUM: HOW IT AFFECTS YOUR HEALTH. Lifestyle, 2013, July In Article.

13. Doll H, Brown S, Thurston A, Vessey M., Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial. J R Coll Gen Pract.,1989 Sep;39(326):364-8.

14. UMass Amherst News Office. Bertone-Johnson research identifies PMS as an early marker for future high blood pressure risk; UMass Amherst News Office, November 24, 2015; Courtesy).

15. Leo MA, Lieber CS. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr. 1999 Jun;69(6):1071-85.

16. Napoli, J.L., Posch, K.C., Fiorella, P.D., Boerman, M.H.E.M., Salerno, G.J., and Burns, R.D. Roles of cellular retinol-binding protein and cellular retinoic acid- binding protein in the metabolic channeling of retinoids. In: “Retinoids,” Livrea, M.A. and Lacker, L. (eds). New York: Marcel Dekker. (1993)

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21. Zava DT, Dollbaum CM, Blen M., Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998;217:369-378.